Liu Huan (1983-), Master of Science (First Class Honours), The University of Auckland.

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Epidemiology 2 (1) : The Airborne Heavy Metal Pollution and Microbes

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发表于 2021-1-3 17:21:56 | 显示全部楼层 |阅读模式
This is the article 2 (1) in the theme 'Environmental Physiology/环境生理学' of Journal of Environment and Health Science.

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2016. Copyrights Register Information: The majority of these materials are registered as book '著作权人:刘焕;作品:《研究生文凭进展(第三版)》' 2016, which can be cataloged in National Copyright Database: http://qgzpdj.ccopyright.com.cn/

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 楼主| 发表于 2021-9-13 10:52:00 | 显示全部楼层
Article 2-1. Epidemiology: The Airborne Heavy Metal Pollution andMicrobes/病理传播学环境空气重金属微生物
Author: Liu Huan(1983- ), Master of Science (First Class Honours), The University of Auckland.
1. Review of Atmospheric Heave Metal Pollution and Microbes
1.The Heavy Metal Pollution
The pollution sources of heavy metal are mainly through three pathways: the aerosol, diet and water environment[1]. This chapter focus on the atmospheric pathway of heavy metal pollution with the representative pollutants of lead and mercury.
1.1.The Pathology of Heavy Metal Toxicity
The toxic heavy metal associates with the pathology of all organs, with particularly attention to the kidney as the most sensitive organ to the toxicity of heavy metal. There are some identified mechanism of pathology in kidney caused by the toxic heavy metal pollution[2]:
1.1.1.Alteration of permeability and transport function in cellular membrane
Heavy metal inactivates the membrane lipid, leading to the alteration of permeability and transport function in cellular membrane.
1.1.2.Impact on the enzyme and nuclein
In cell, the heavy metal react with organic molecules or the functional group of enzyme, which results in the exchange of essential metal ions or inactivation of enzymes. The heavy metal ions also combine the non-enzymatic protein and nucleic acid, inactivating the biological organs.
1.1.3.Distorting the immunological system
The heavy metals, as half antigens, react with proteins into complex antigens, distorting the immunological system of biological organs.
1.1.4.Secondary pathology
The secondary pathological characteristics associating the heavy metals mainly include methemoglobinemia, hematolysis, shock, anoxia and electrolyte disturbances.
1.2.Pathology of Lead
The main perniciousness of lead is the chronic interstitial nephritis, which has been testified physiologically by the evidence of excessive lead in the inclusion body of renal epithelial cell using animal test. The pathological characteristics of lead toxicity usually include Fanconi-de Toni syndrome, benign glycosuria, amino-aciduria, albuminuria, cylindruria, urine lead ascending and hypertension etc. Approximately 50% of patients of toxic lead are associated with pathological characteristics of hyperuricemia, arthrolithiasis, and osteosclerosis in bone X-ray (typical increase of texture in the end of long bone)[2].
1.3.Pathology of Mercury
The physiological mechanism caused by mercury is that the mercury combines with sulfur hydrogen group of mitochondrial membrane protein, resulting in the decomposition and destruction of mitochondria and nuclei. The compounds of plasma mercury tightly combines with proteins, allowing only 1% of glomerulus to permeate. The accumulation of mercury intensively occurs in the proximal tubule of kidney, manifesting the formation of granule in epithelial cells or vacuolar degeneration with serious pathology as focal tubular rupture. The acute characteristics of pathology include the renal failure, urine dipstick for protein, cast epithelial, the increase of red-blood-cells, diabetes, acidaminuria, and mercury urine, as well as chronic characteristics of nephrosis syndrome[2].
2.The Airborne Microbial Pollution
Acute respiratory infection is divided into anemofrigid cold and anemopyretic cold by Traditional Chinese Medicine (TCM) [3]. The population density and microbial diversity of aerosol samples in oral cavity were compared between the heathy one and patients by Chen et al.,(2005)[3]. However, the patients are diagnosed as anemofrigid cold and anemopyretic cold by TCM separately, which are correspondingly compared independently as well. The background microbial ecosystem are sampled and analyzed in this research for the assessment of meteorological effects on the microbial communities. The conclusion of this research supports the theory of ‘alteration of eco-balance’ in microbial ecosystem revealed by the increase of microbial density and decrease of microbial diversity, which is considered as the causal factor of acute respiratory infection. However, the specific pathogenesis of each microbial species  has not been characterized in this research, and the classification of microbial species is based on the morphological characters only. Particularly, the establishment of pathogens is performed as a microbial community rather than a population of single species in this research, which further supports the improvement of biological control pointed by this book author [4].
2. Examination of Environmental Toxicity
This article designed the methods of examination of environmental toxicity in heavy metal pollution adhering to aerosol:
Step 1: two parallel samples of rats, as the receptors of heavy metal pollution, are exposed to two kinds of environmental conditions respectively for the same duration: one is adjacent to the transportation road where the main pollution source of heavy metal is diesel; the other is the factory in which the pollution source of heavy metal is the industrial emission. The height of rat samples should be located at the level of people’s breath zone. The rat’s total urine during two hours after exposure experiment is collected for analysis.
Step 2: The cumulative exposure dose of heavy metal pollution adhering to aerosol  are monitored in both sites, and the test of mean heavy metal concentration in the urine after exposure experiment are correspondingly conducted for the analysis of correlation. The standards of monitoring the heavy metal pollution include: GB/T16157, HJ/T 373, and HJ/T48...etc.
Step 3. The ratio of mean heavy metal concentration in urine to the cumulative exposure dose is calculated, for the assessment of the difference in environmental toxicity between two different emission sources, which emit aerosols with different morphology. The mean heavy metal concentration in the urine after exposure experiment is compared with relevant standards of limit value to reveal the degree of health (The higher concentration, the more environmental toxicity).
Step 4. The total content of heavy metal in the urine after exposure experiment is also counted, which is divided by the cumulative exposure dose so that another ratio is worked out for the assessment of environmental toxicity (The higher ratio, the more environmental toxicity).
Step5. 8-hours exposure duration, 24-hours exposure duration and long-term exposure duration are chosen for the investigation of environmental toxicity in heavy metal at different durations.
Step 6. After multiple test, the mean ratio becomes a stable criterion to examine the effects of the environmental toxicity in heavy metal pollution.
Step 7. The mean heavy metal concentration in urine is also tested in people who are working in both sites as ‘clinical trial’, and the correlation between the cumulative exposure dose and mean heavy metal concentration in urine is analyzed. The mean heavy metal concentration in the urine after exposure experiment is compared with relevant standards of limit value to reveal the degree of health.
This is the revised materials in book “Proceedings for Degree of Postgraduate Diploma in Environmental Science (3rd Edition).” published in 2016. Secondly Revised on 28/12/2020; Thirdly revised on 13/09/2021.  
References:
[1]. 唐银栋(1987)。重金属的结构与其环境污染和毒性的关系。《内蒙古医学院学报》。
第 9 卷,第 1 期。
[2]许国章,樊军明(1995)。重金属中毒性肾脏病。《新医学》。
[3]. 陈文慧, 袁嘉丽, 韩妮萍, 姚政, 张英凯, 赵鹏 (2005)。 春季时令病邪与空气微生物及呼吸道微生态相关性初步研究。《云南中医学院学报》。第 28 卷第 4 期。
[4].Liu Huan (2015). Review of Biological Control: The Population Biology of Microbial Ecosystem/种群生物学原理在微生物生态系统和生物控制技术中的应用研究(英文). Journal of Environmental & Health Science.

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 楼主| 发表于 2021-1-3 17:23:03 | 显示全部楼层
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 楼主| 发表于 2021-1-6 10:12:32 | 显示全部楼层
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 楼主| 发表于 2021-8-27 14:50:55 | 显示全部楼层
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