There are three main parts with regards to the topic ‘specificity in the interaction between pathogen invasion and host organism’: firstly, the specificity in population genetics between invasive pathogen genotype and host genotype (including specific host cells, tissue, organ or individual); secondly, the specificity in metabolic biochemistry pathways between invasive pathogen phenotype and host phenotype, which is further discussed below; third, the specificity in cultural or ecological conditions (such as specific season, geography site, pathogen transmission pathways [4]) between pathogen invasion and host organism.
A novel matrix of Matrix Xsum is designed for the classification across different bio-samples of host cells [1]. However, This classification methods is also applicable on the identification of virus phenotype in the invasion-host experiment designed in my another article [2], and a combination of both genotype and phenotype classification method has been designed in my bacterial article previously [3]. Both virus and bacterial classification would help to improve the accuracy in the identification of pathogen strains. This is especially for epidemic pathogens with broad infection rate (such as COVID 19), because if there is only one indicator (such as genotype) to analyze, the specificity in the interaction between pathogen invasion and host organism may not be apparent, but the specific virus strain would be much more accurately identified once there are comprehensive indicators selected to analyze below, targeting specific host population.
Based on the specificity in the interaction between pathogen invasion and host organism, this article designs a new table covering the systematic indicators to identify and classify the pathogen strains.
Table 1. The systematic indicators identifying and classifying the pathogen strains.
| Pathogen genotype | Pathogen phenotype | Host cell genotypes infected | Host cell phenotypes infected | Host cell genotypes and phenotypes with apparent immunology | Season to break out | Geography distribution (Is it origin?) | Pathogen transmission pathways |
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An original review essay is coming as the first study plan in this year (not less than 10 000 words in English)......
[1]. Liu Huan. (2021). Metabolomics and Application on The Specificity of Host-Invasion Interaction. Journal of Environment and Health Science (ISSN 2314-1628). Feb. 2021.
[2]. Liu Huan. (2021). The Identification of Pathogen Phenotype for Biophysical Simulation. Journal of Environment and Health Science (ISSN 2314-1628), 2021(02).
[3]. Liu Huan. (2021). Classification of Bacteria by DNA Genetic Marker and Its Theory. Journal of Environment and Health Science (ISSN 2314-1628), 2021(02).
[4]. Liu Huan (2022). Epidemiology------Comparison between indoor and outdoor air quality at three representative sites in Auckland Center. Journal of Environment and Health Science (ISSN 2314-1628), 2022(12).
发表于 2023-1-13 17:39:30