hliu092 发表于 2021-1-27 17:27:35

Metabolomics (1): The Systematic Chemistry Fingerprints/新陈代谢组学之一

This is the article 7 in the theme 'Environmental Physiology/环境生理学' of Journal of Environment and Health Science.

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hliu092 发表于 2021-12-20 10:30:35

Article 7: Metabolomics (1) --- The Systematic Chemistry Fingerprints Between Genotype and Phenotype and its Application on the Conservation Genetics /新陈代谢组学---连接基因型和表现型的一项系统化学指纹识别技术与在保护遗传学中的应用
Author: Liu Huan (1983-), Master of Science (First Class Honours), The University of Auckland
1. IntroductionDNA should be defined as the main carrier of material genetic information. Because cells are intelligent creatures, in addition to material genetic information, there are also memory of spirit passed on to the offspring cells in the genetic process. This has been discussed in my previous paper. After genetics, complex metabolic processes begins in cells, which can be divided into three categories in this article: primary metabolic molecules (such as tRNA), secondary metabolic biochemistry molecules (such as glutamic acid discussed in plant physiology paper), and the final metabolites (such as polysaccharide compounds). However, enzyme is the indispensable biochemicals in this metabolic process. Enzyme is the principal biochemical regulator to initiate the biochemical process of metabolism in cell biology. The primary and secondary metabolites can be significantly influenced by the cellular physiological environment and genetics, whereas the cell functions constantly relies on the regulator of isozyme family (there are various enzyme species within one isozyme family) initiating the pathways of various metabolite process regardless of environmental changes and genetics. For example, in my previous article, it is concluded that the isozyme spectrum correspondingly to the valid antibiotics of specific pathogens must be relatively specific and unique, regardless of DNA genetics and environmental changes between different host cells. The thinking ability of multi-cellular individuals of higher intelligent is limited to three-dimension, as the thinking ability of single-cell organisms should only stay in two dimension: the recognition of bio-signals and utilization of biological enzymes. The enzyme utilization capacity can be ‘learned’ by cells. The previous paper has discussed the intelligence of cells. 2. Key features of metabolomics in this paper:1. Succession of study focus on the metabolic biochemistry pathways from primary metabolites to final metabolites, but choose enzymes as the indicator of metabolic reaction pathways;2.Compared with previous enzyme spectroscopy, this article designed the novel matrix calculation methods to systematically analyze the cell function regulation pathway, because the environment adaptability trait of cell (such as a specific pathogen resistance) is functioned by multiple metabolic pathways to regulate a number of sub-functions, and the multiple sub-functions and pathways are not independent of each other;3. It connects genotypes with phenotypes to distinguish which functions of cells are inherited and which need to be cultivated. 译文:细胞结构生物中DNA分子应当准确定义为物质遗传信息的主要载体。因为细胞是有智力的,遗传过程中除了物质遗传信息,还有精神记忆机制。这在我之前的论文中已经论述。那么在此后,细胞中开始了复杂的新陈代谢过程,这里可以区分为初级代谢生化分子(如tRNA),次级代谢生化分子(如本人在植物逆境生理中论述的glutamic acid),和最终代谢生化分子(如多糖化合物)。其中不可缺少的就是酶。酶是细胞生物中对新陈代谢生化过程进行调节的首要生化指标。初级和次级代谢生化分子既可以受遗传DNA影响、也可以受细胞环境的影响而显著发生变异特性,但是细胞生理功能的调节,仅仅通过调节同工酶酶谱的合成和分泌作为生化反应链中首要途径(在同一同工酶家族中有许多不同的酶种类),不管DNA先天遗传和细胞环境变化因素。比如,在本人之前文章已经论述,针对特定病原体的抗体,不管宿主细胞DNA遗传变异特性,也不管细胞环境的变化,细胞内合成针对特定病原体的有效抗体的同工酶谱都是相对唯一性和特定性。正如本文已经论述多细胞高等智慧生物的思维局限于三维思维能力,而单细胞生物的智力思维能力应该仅仅停留在识别生物信号和运用生物酶两个维度而已。而细胞生物对生物酶的识别与合成可以是后天培养的。本文已经在细胞“智慧”一文中论述了细胞的思维。 本文中新陈代谢组学的特点:1.继承从初级代谢物到最终代谢物中对新陈代谢生化反应途径/路径作为重点研究方向,但是选择以酶作为新陈代谢反应途径的指示性指标;2.与之前酶谱学相比,本文设计了一个新的矩阵算式方法系统地对细胞生物功能调节途径进行分析,因为细胞环境适应性中的某一性状(比如对某一病原体实现抗病性),是由于细胞在多项功能、多个新陈代谢途径进行调节的结果,而且细胞各功能、各个新陈代谢途径之间一定是相互关联,非独立的。3.连接了基因型和表现型,区分细胞哪些功能是先天遗传获取的,哪些功能需要后天培养的。
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Acknowledge:
Advice on the section 5 (yield components and nitrogen fixation content) of this article: Hill, G. D. & Mckenzie, B. A.Lincoln University, New Zealand. 2007.
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